ARA-290 (16mg)
Especificaciones técnicas
| Pureza (HPLC) | ≥98% (HPLC) |
| Número CAS | 1208243-50-8 |
| Forma | White lyophilized powder |
| Almacenamiento | -20°C |
| Secuencia | pGlu-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser |
| Peso molecular | 1,257.4 g/mol |
| Forma salina | Acetate |
| Solubilidad | Soluble in water |
ARA-290 (16mg)
Precio de lista en EUR · HU, SK, CZ, PL
- Eurozone (EUR)135,00 EUR
- Hungría (HU)135,00 EUR≈ 54 000 Ft
- Eslovaquia (SK)135,00 EUR
- Chequia (CZ)135,00 EUR≈ 3 375 Kč
- Polonia (PL)135,00 EUR≈ 573,75 zł
Mismo precio de lista en EUR para envío a Hungría, Eslovaquia, República Checa y Polonia. El pago se cobra en EUR.
HUF/CZK/PLN indicativos convertidos desde EUR; Eslovaquia usa EUR. Tasas aproximadas. Cobro en EUR.
Erythropoietin-derived 11-mer — innate repair receptor agonist for anti-inflammatory research. 16mg vial.
Estrictamente para investigación de laboratorio.
No apto para consumo humano, uso veterinario ni diagnóstico.
From the Peptide Explorer
An 11-amino-acid peptide derived from the tissue-protective domain of erythropoietin. It selectively binds the heterodimeric innate repair receptor (EPOR/βcR) expressed on injured tissue—triggering the cytoprotective and anti-inflammatory arm of EPO signaling without stimulating hematopoiesis via the classic EPOR homodimer.
Key Mechanisms
- ›Innate repair receptor (EPOR/βcR) agonism
- ›JAK2-STAT signaling in injured tissue
- ›Reduction of pro-inflammatory cytokines (TNF-α, IL-6)
- ›Endothelial protection against ischemic injury
- ›Promotion of peripheral nerve regeneration
Primary Research Areas
- ›Sarcoidosis-associated small-fiber neuropathy
- ›Diabetic peripheral neuropathy
- ›Ischemic injury and reperfusion
- ›Chronic inflammation research
Key Research Findings
- Improved corneal nerve fibre density and pain scores in sarcoid small-fiber neuropathy (Brines et al., Mol Med 2014)
- Reduced neuropathic pain in phase-2 diabetic neuropathy trial (Dahan et al., 2013)
- Tissue-protective activity without altering haematocrit in rodent and primate models
Research Overview
An 11-amino-acid peptide derived from the tissue-protective domain of erythropoietin. It selectively binds the heterodimeric innate repair receptor (EPOR/βcR) expressed on injured tissue—triggering the cytoprotective and anti-inflammatory arm of EPO signaling without stimulating hematopoiesis via the classic EPOR homodimer.
Origin: Synthetic peptide derived from the aqueous face of helix B of erythropoietin (EPO); engineered to retain tissue-protective activity without hematopoiesis
Mechanism of Action
- Innate repair receptor (EPOR/βcR) agonism
- JAK2-STAT signaling in injured tissue
- Reduction of pro-inflammatory cytokines (TNF-α, IL-6)
- Endothelial protection against ischemic injury
- Promotion of peripheral nerve regeneration
Primary Research Areas
- Sarcoidosis-associated small-fiber neuropathy
- Diabetic peripheral neuropathy
- Ischemic injury and reperfusion
- Chronic inflammation research
Key Published Findings
- Improved corneal nerve fibre density and pain scores in sarcoid small-fiber neuropathy (Brines et al., Mol Med 2014)
- Reduced neuropathic pain in phase-2 diabetic neuropathy trial (Dahan et al., 2013)
- Tissue-protective activity without altering haematocrit in rodent and primate models
Research Protocol
Commonly studied routes: Subcutaneous. Reconstitute with bacteriostatic water. Consult published literature for dose ranges; use our Peptide Calculator for volumetric preparation.
Storage
-20°C lyophilized
Important Notice
ARA-290 (16mg) is supplied for laboratory research use only (RUO). Not for human or veterinary use, diagnostics, or therapeutics.
Especificaciones de investigación
Synthesized for strict analytical consistency. Verified via HPLC/MS.Ver estándares de calidad →
Manipulación y almacenamiento
- Store lyophilized at -20°C
- Protect from light and moisture
- Use sterile bacteriostatic water for reconstitution
- Minimize freeze-thaw cycles
- Solubility: Soluble in water