GHRP-6, GHRP-2, and Ipamorelin: GH Secretagogue Research Landscape

### Ghrelin receptor pathway GHRP-6 and GHRP-2 are synthetic **growth hormone–releasing peptides** that activate the ghrelin receptor (GHS-R1a) on pituitary somatotrophs, provoking GH release. Older GHRP generations may raise **prolactin** or **cortisol** in some models—researchers weigh those off-targets when designing studies. ### Ipamorelin’s selectivity Ipamorelin is often described as a **more selective** secretagogue in literature, with reduced impact on prolactin and ACTH/cortisol axes compared with earlier GHRPs—making it a common comparator in pituitary research. ### Choosing a research tool Selection depends on your model: pulse dynamics, off-target sensitivity, and pairing with GHRH analogs (see /blog/cjc-1295-ipamorelin-mechanism). ### RUO Not for human consumption. Laboratory research only. *GHRP-6, GHRP-2, and ipamorelin are listed in our catalog for research procurement.*