System Entry • 12/27/2025
MOTS-c: The Mitochondrial Key to Metabolic Flexibility
Investigating the exercise-mimetic effects of the Mitochondrial-Derived Peptide MOTS-c.
### A New Class of Peptide
MOTS-c is unique. It is not encoded by the cell's nucleus but by the mitochondria itself. It acts as a signaling molecule that helps regulate systemic metabolism, essentially communicating the mitochondrial state to the rest of the body.
### Exercise in a Vial?
Research highlights MOTS-c's ability to prevents age-induced insulin resistance and diet-induced obesity in mouse models. It effectively mimics the metabolic benefits of exercise by:
- Enhancing glucose uptake in muscle cells.
- Promoting fatty acid oxidation.
- Regulating nuclear gene expression involved in metabolism.
This makes it a prime candidate for research into metabolic syndrome and longevity.
*Unlock cellular energy research with MOTS-c from peptide limited.*


