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System Entry • 12/27/2025

MOTS-c: The Mitochondrial Key to Metabolic Flexibility

Investigating the exercise-mimetic effects of the Mitochondrial-Derived Peptide MOTS-c.

### A New Class of Peptide MOTS-c is unique. It is not encoded by the cell's nucleus but by the mitochondria itself. It acts as a signaling molecule that helps regulate systemic metabolism, essentially communicating the mitochondrial state to the rest of the body. ### Exercise in a Vial? Research highlights MOTS-c's ability to prevents age-induced insulin resistance and diet-induced obesity in mouse models. It effectively mimics the metabolic benefits of exercise by: - Enhancing glucose uptake in muscle cells. - Promoting fatty acid oxidation. - Regulating nuclear gene expression involved in metabolism. This makes it a prime candidate for research into metabolic syndrome and longevity. *Unlock cellular energy research with MOTS-c from peptide limited.*

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