ARA-290 (16mg)
Technické specifikace
| Čistota (HPLC) | ≥98% (HPLC) |
| CAS číslo | 1208243-50-8 |
| Forma | White lyophilized powder |
| Skladování | -20°C |
| Sekvence | pGlu-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser |
| Molekulová hmotnost | 1,257.4 g/mol |
| Solná forma | Acetate |
| Rozpustnost | Soluble in water |
ARA-290 (16mg)
Katalogová cena v EUR · HU, SK, CZ, PL
- Eurozone (EUR)135,00 EUR
- Maďarsko (HU)135,00 EUR≈ 54 000 Ft
- Slovensko (SK)135,00 EUR
- Česko (CZ)135,00 EUR≈ 3 375 Kč
- Polsko (PL)135,00 EUR≈ 573,75 zł
Stejná katalogová cena v EUR při doručení do Maďarska, Slovenska, Česka a Polska. Platba v EUR.
Orientační HUF/CZK/PLN přepočteno z EUR; Slovensko používá EUR. Kurzy přibližné. Platba v EUR.
Erythropoietin-derived 11-mer — innate repair receptor agonist for anti-inflammatory research. 16mg vial.
Pouze pro laboratorní výzkum.
Není určeno pro lidskou spotřebu, veterinární ani diagnostické použití.
From the Peptide Explorer
An 11-amino-acid peptide derived from the tissue-protective domain of erythropoietin. It selectively binds the heterodimeric innate repair receptor (EPOR/βcR) expressed on injured tissue—triggering the cytoprotective and anti-inflammatory arm of EPO signaling without stimulating hematopoiesis via the classic EPOR homodimer.
Key Mechanisms
- ›Innate repair receptor (EPOR/βcR) agonism
- ›JAK2-STAT signaling in injured tissue
- ›Reduction of pro-inflammatory cytokines (TNF-α, IL-6)
- ›Endothelial protection against ischemic injury
- ›Promotion of peripheral nerve regeneration
Primary Research Areas
- ›Sarcoidosis-associated small-fiber neuropathy
- ›Diabetic peripheral neuropathy
- ›Ischemic injury and reperfusion
- ›Chronic inflammation research
Key Research Findings
- Improved corneal nerve fibre density and pain scores in sarcoid small-fiber neuropathy (Brines et al., Mol Med 2014)
- Reduced neuropathic pain in phase-2 diabetic neuropathy trial (Dahan et al., 2013)
- Tissue-protective activity without altering haematocrit in rodent and primate models
Research Overview
An 11-amino-acid peptide derived from the tissue-protective domain of erythropoietin. It selectively binds the heterodimeric innate repair receptor (EPOR/βcR) expressed on injured tissue—triggering the cytoprotective and anti-inflammatory arm of EPO signaling without stimulating hematopoiesis via the classic EPOR homodimer.
Origin: Synthetic peptide derived from the aqueous face of helix B of erythropoietin (EPO); engineered to retain tissue-protective activity without hematopoiesis
Mechanism of Action
- Innate repair receptor (EPOR/βcR) agonism
- JAK2-STAT signaling in injured tissue
- Reduction of pro-inflammatory cytokines (TNF-α, IL-6)
- Endothelial protection against ischemic injury
- Promotion of peripheral nerve regeneration
Primary Research Areas
- Sarcoidosis-associated small-fiber neuropathy
- Diabetic peripheral neuropathy
- Ischemic injury and reperfusion
- Chronic inflammation research
Key Published Findings
- Improved corneal nerve fibre density and pain scores in sarcoid small-fiber neuropathy (Brines et al., Mol Med 2014)
- Reduced neuropathic pain in phase-2 diabetic neuropathy trial (Dahan et al., 2013)
- Tissue-protective activity without altering haematocrit in rodent and primate models
Research Protocol
Commonly studied routes: Subcutaneous. Reconstitute with bacteriostatic water. Consult published literature for dose ranges; use our Peptide Calculator for volumetric preparation.
Storage
-20°C lyophilized
Important Notice
ARA-290 (16mg) is supplied for laboratory research use only (RUO). Not for human or veterinary use, diagnostics, or therapeutics.
Výzkumné specifikace
Synthesized for strict analytical consistency. Verified via HPLC/MS.Zobrazit standardy kvality →
Manipulace a skladování
- Store lyophilized at -20°C
- Protect from light and moisture
- Use sterile bacteriostatic water for reconstitution
- Minimize freeze-thaw cycles
- Solubility: Soluble in water