NAD+ (500mg)
Technické specifikace
| Čistota (HPLC) | ≥98% (HPLC) |
| CAS číslo | 53-84-9 |
| Forma | White lyophilized powder |
| Skladování | -20°C |
| Sekvence | Dinucleotide coenzyme (nicotinamide + adenine ribose phosphates), not a peptide |
| Molekulová hmotnost | 663.43 g/mol |
| Solná forma | Acetate |
| Rozpustnost | Highly water-soluble |
NAD+ (500mg)
Katalogová cena v EUR · HU, SK, CZ, PL
- Eurozone (EUR)224,10 EUR
- Maďarsko (HU)224,10 EUR≈ 89 640 Ft
- Slovensko (SK)224,10 EUR
- Česko (CZ)224,10 EUR≈ 5 603 Kč
- Polsko (PL)224,10 EUR≈ 952,43 zł
Stejná katalogová cena v EUR při doručení do Maďarska, Slovenska, Česka a Polska. Platba v EUR.
Orientační HUF/CZK/PLN přepočteno z EUR; Slovensko používá EUR. Kurzy přibližné. Platba v EUR.
Nicotinamide Adenine Dinucleotide for cellular metabolism research.
Mechanism: Cofactor for mitochondrial respiration, activates sirtuins (SIRT1-7), substrate for PARPs.
Applications: Aging, mitochondrial dysfunction, DNA repair.
Note: Highly hygroscopic—minimize air exposure. Use within 24h of reconstitution.
Pouze pro laboratorní výzkum.
Není určeno pro lidskou spotřebu, veterinární ani diagnostické použití.
From the Peptide Explorer
A pyridine dinucleotide coenzyme central to oxidative metabolism, the sirtuin family of deacetylases, the PARP family of DNA-repair enzymes, and CD38 ectoenzyme signaling. Cellular NAD+ levels decline markedly with age — a phenomenon directly implicated in mitochondrial dysfunction and many hallmarks of aging.
Key Mechanisms
- ›Hydride carrier in redox reactions (NAD+/NADH)
- ›Cosubstrate for sirtuin-family deacylases (SIRT1-7)
- ›Substrate for PARP-family DNA-damage response enzymes
- ›Substrate for CD38 cyclic-ADP-ribose signaling
- ›Regulator of circadian-clock CLOCK:BMAL1 activity
Primary Research Areas
- ›Geroscience and ageing
- ›Mitochondrial dysfunction
- ›Neurodegeneration and DNA repair
- ›Metabolic dysfunction (NAFLD, insulin resistance)
- ›Circadian biology
Key Research Findings
- Supplementation with NAD+ precursors restored mitochondrial function in aged mice (Gomes et al., Cell 2013)
- NAD+ decline is a hallmark of ageing across tissues (Verdin, Science 2015)
- Sirtuin activity is rate-limited by NAD+ availability
Research Overview
A pyridine dinucleotide coenzyme central to oxidative metabolism, the sirtuin family of deacetylases, the PARP family of DNA-repair enzymes, and CD38 ectoenzyme signaling. Cellular NAD+ levels decline markedly with age — a phenomenon directly implicated in mitochondrial dysfunction and many hallmarks of aging.
Origin: Essential coenzyme present in every living cell; biosynthesized from tryptophan, nicotinic acid, or nicotinamide riboside
Mechanism of Action
- Hydride carrier in redox reactions (NAD+/NADH)
- Cosubstrate for sirtuin-family deacylases (SIRT1-7)
- Substrate for PARP-family DNA-damage response enzymes
- Substrate for CD38 cyclic-ADP-ribose signaling
- Regulator of circadian-clock CLOCK:BMAL1 activity
Primary Research Areas
- Geroscience and ageing
- Mitochondrial dysfunction
- Neurodegeneration and DNA repair
- Metabolic dysfunction (NAFLD, insulin resistance)
- Circadian biology
Key Published Findings
- Supplementation with NAD+ precursors restored mitochondrial function in aged mice (Gomes et al., Cell 2013)
- NAD+ decline is a hallmark of ageing across tissues (Verdin, Science 2015)
- Sirtuin activity is rate-limited by NAD+ availability
Research Protocol
Commonly studied routes: Intravenous, Subcutaneous. Reconstitute with bacteriostatic water. Consult published literature for dose ranges; use our Peptide Calculator for volumetric preparation.
Storage
-20°C lyophilized, desiccated, protect from light
Important Notice
NAD+ (500mg) is supplied for laboratory research use only (RUO). Not for human or veterinary use, diagnostics, or therapeutics.
Výzkumné specifikace
Synthesized for strict analytical consistency. Verified via HPLC/MS.Zobrazit standardy kvality →
Manipulace a skladování
- Store lyophilized at -20°C
- Protect from light and moisture
- Use sterile bacteriostatic water for reconstitution
- Minimize freeze-thaw cycles
- Solubility: Highly water-soluble