5-Amino-1MQ (10mg)
Specyfikacja techniczna
| Czystość (HPLC) | ≥98% (HPLC) |
| Numer CAS | 85691-30-5 |
| Forma | White lyophilized powder |
| Przechowywanie | -20°C |
| Sekwencja | Small-molecule (quinolinium scaffold), not a peptide |
| Masa cząsteczkowa | 159.19 g/mol |
| Forma soli | Acetate |
| Rozpuszczalność | Soluble in water and DMSO |
5-Amino-1MQ (10mg)
Cena katalogowa w EUR · HU, SK, CZ, PL
- Eurozone (EUR)40,00 EUR
- Węgry (HU)40,00 EUR≈ 16 000 Ft
- Słowacja (SK)40,00 EUR
- Czechy (CZ)40,00 EUR≈ 1 000 Kč
- Polska (PL)40,00 EUR≈ 170,00 zł
Ta sama cena katalogowa w EUR przy dostawie na Węgry, Słowację, Czechy i Polskę. Płatność w EUR.
Orientacyjne kwoty HUF, CZK i PLN przeliczone z EUR; Słowacja stosuje EUR. Kursy przybliżone. Płatność w EUR.
5-Amino-1MQ — drobnocząsteczkowy inhibitor NNMT badany w modelach otyłości, metabolizmu tkanki tłuszczowej i chorób metabolicznych. Wyłącznie RUO — do badań laboratoryjnych; nie do spożycia przez ludzi.
Wyłącznie do badań laboratoryjnych.
Nie do spożycia przez ludzi, zastosowań weterynaryjnych ani diagnostycznych.
From the Peptide Explorer
A potent, selective, cell-permeable small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT). NNMT is overexpressed in obese adipose tissue and ageing muscle, where it depletes the methyl donor SAM and generates the metabolically inert 1-methylnicotinamide. Inhibiting NNMT restores SAM and NAD+ precursor pools, reactivating lipolysis and myogenesis.
Key Mechanisms
- ›Selective NNMT enzyme inhibition
- ›Restoration of SAM (methyl donor) levels
- ›Increased NAD+ precursor availability
- ›Enhanced adipocyte lipolysis
- ›Stimulation of satellite-cell-driven myogenesis
Primary Research Areas
- ›Diet-induced obesity models
- ›Sarcopenia and muscle regeneration
- ›NAD+ metabolism
- ›Methyl-donor biochemistry
Key Research Findings
- Reduced white adipose mass and improved insulin sensitivity in diet-induced obese mice (Neelakantan et al., 2018)
- Restored myogenic capacity and muscle mass in aged mouse models (Dimet-Wiley et al., 2022)
- Depletion of 1-methylnicotinamide and restoration of intracellular SAM
Research Overview
A potent, selective, cell-permeable small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT). NNMT is overexpressed in obese adipose tissue and ageing muscle, where it depletes the methyl donor SAM and generates the metabolically inert 1-methylnicotinamide. Inhibiting NNMT restores SAM and NAD+ precursor pools, reactivating lipolysis and myogenesis.
Origin: Rationally designed small-molecule NNMT inhibitor (Saint Louis University)
Mechanism of Action
- Selective NNMT enzyme inhibition
- Restoration of SAM (methyl donor) levels
- Increased NAD+ precursor availability
- Enhanced adipocyte lipolysis
- Stimulation of satellite-cell-driven myogenesis
Primary Research Areas
- Diet-induced obesity models
- Sarcopenia and muscle regeneration
- NAD+ metabolism
- Methyl-donor biochemistry
Key Published Findings
- Reduced white adipose mass and improved insulin sensitivity in diet-induced obese mice (Neelakantan et al., 2018)
- Restored myogenic capacity and muscle mass in aged mouse models (Dimet-Wiley et al., 2022)
- Depletion of 1-methylnicotinamide and restoration of intracellular SAM
Research Protocol
Commonly studied routes: Oral, Subcutaneous. Reconstitute with bacteriostatic water. Consult published literature for dose ranges; use our Peptide Calculator for volumetric preparation.
Storage
-20°C desiccated; protect from light
Important Notice
5-Amino-1MQ (10mg) is supplied for laboratory research use only (RUO). Not for human or veterinary use, diagnostics, or therapeutics.
Specyfikacja badawcza
Synthesized for strict analytical consistency. Verified via HPLC/MS.Zobacz standardy jakości →
Przechowywanie i obsługa
- Store lyophilized at -20°C
- Protect from light and moisture
- Use sterile bacteriostatic water for reconstitution
- Minimize freeze-thaw cycles
- Solubility: Soluble in water and DMSO