ARA-290 (16mg)
Specyfikacja techniczna
| Czystość (HPLC) | ≥98% (HPLC) |
| Numer CAS | 1208243-50-8 |
| Forma | White lyophilized powder |
| Przechowywanie | -20°C |
| Sekwencja | pGlu-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser |
| Masa cząsteczkowa | 1,257.4 g/mol |
| Forma soli | Acetate |
| Rozpuszczalność | Soluble in water |
ARA-290 (16mg)
Cena katalogowa w EUR · HU, SK, CZ, PL
- Eurozone (EUR)150,00 EUR
- Węgry (HU)150,00 EUR≈ 60 000 Ft
- Słowacja (SK)150,00 EUR
- Czechy (CZ)150,00 EUR≈ 3 750 Kč
- Polska (PL)150,00 EUR≈ 637,50 zł
Ta sama cena katalogowa w EUR przy dostawie na Węgry, Słowację, Czechy i Polskę. Płatność w EUR.
Orientacyjne kwoty HUF, CZK i PLN przeliczone z EUR; Słowacja stosuje EUR. Kursy przybliżone. Płatność w EUR.
ARA-290 (cibinetide) — 11-aminokwasowy peptyd aktywujący hetero-receptor innate repair; w literaturze w modelach neuropatii i gojenia tkanek. Wyłącznie RUO — do badań laboratoryjnych; nie do spożycia przez ludzi.
Wyłącznie do badań laboratoryjnych.
Nie do spożycia przez ludzi, zastosowań weterynaryjnych ani diagnostycznych.
From the Peptide Explorer
An 11-amino-acid peptide derived from the tissue-protective domain of erythropoietin. It selectively binds the heterodimeric innate repair receptor (EPOR/βcR) expressed on injured tissue—triggering the cytoprotective and anti-inflammatory arm of EPO signaling without stimulating hematopoiesis via the classic EPOR homodimer.
Key Mechanisms
- ›Innate repair receptor (EPOR/βcR) agonism
- ›JAK2-STAT signaling in injured tissue
- ›Reduction of pro-inflammatory cytokines (TNF-α, IL-6)
- ›Endothelial protection against ischemic injury
- ›Promotion of peripheral nerve regeneration
Primary Research Areas
- ›Sarcoidosis-associated small-fiber neuropathy
- ›Diabetic peripheral neuropathy
- ›Ischemic injury and reperfusion
- ›Chronic inflammation research
Key Research Findings
- Improved corneal nerve fibre density and pain scores in sarcoid small-fiber neuropathy (Brines et al., Mol Med 2014)
- Reduced neuropathic pain in phase-2 diabetic neuropathy trial (Dahan et al., 2013)
- Tissue-protective activity without altering haematocrit in rodent and primate models
Research Overview
An 11-amino-acid peptide derived from the tissue-protective domain of erythropoietin. It selectively binds the heterodimeric innate repair receptor (EPOR/βcR) expressed on injured tissue—triggering the cytoprotective and anti-inflammatory arm of EPO signaling without stimulating hematopoiesis via the classic EPOR homodimer.
Origin: Synthetic peptide derived from the aqueous face of helix B of erythropoietin (EPO); engineered to retain tissue-protective activity without hematopoiesis
Mechanism of Action
- Innate repair receptor (EPOR/βcR) agonism
- JAK2-STAT signaling in injured tissue
- Reduction of pro-inflammatory cytokines (TNF-α, IL-6)
- Endothelial protection against ischemic injury
- Promotion of peripheral nerve regeneration
Primary Research Areas
- Sarcoidosis-associated small-fiber neuropathy
- Diabetic peripheral neuropathy
- Ischemic injury and reperfusion
- Chronic inflammation research
Key Published Findings
- Improved corneal nerve fibre density and pain scores in sarcoid small-fiber neuropathy (Brines et al., Mol Med 2014)
- Reduced neuropathic pain in phase-2 diabetic neuropathy trial (Dahan et al., 2013)
- Tissue-protective activity without altering haematocrit in rodent and primate models
Research Protocol
Commonly studied routes: Subcutaneous. Reconstitute with bacteriostatic water. Consult published literature for dose ranges; use our Peptide Calculator for volumetric preparation.
Storage
-20°C lyophilized
Important Notice
ARA-290 (16mg) is supplied for laboratory research use only (RUO). Not for human or veterinary use, diagnostics, or therapeutics.
Specyfikacja badawcza
Synthesized for strict analytical consistency. Verified via HPLC/MS.Zobacz standardy jakości →
Przechowywanie i obsługa
- Store lyophilized at -20°C
- Protect from light and moisture
- Use sterile bacteriostatic water for reconstitution
- Minimize freeze-thaw cycles
- Solubility: Soluble in water