5-Amino-1MQ (10mg)

Research Overview

A potent, selective, cell-permeable small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT). NNMT is overexpressed in obese adipose tissue and ageing muscle, where it depletes the methyl donor SAM and generates the metabolically inert 1-methylnicotinamide. Inhibiting NNMT restores SAM and NAD+ precursor pools, reactivating lipolysis and myogenesis.

Origin: Rationally designed small-molecule NNMT inhibitor (Saint Louis University)

Mechanism of Action

• Selective NNMT enzyme inhibition

• Restoration of SAM (methyl donor) levels

• Increased NAD+ precursor availability

• Enhanced adipocyte lipolysis

• Stimulation of satellite-cell-driven myogenesis

Primary Research Areas

• Diet-induced obesity models

• Sarcopenia and muscle regeneration

• NAD+ metabolism

• Methyl-donor biochemistry

Key Published Findings

• Reduced white adipose mass and improved insulin sensitivity in diet-induced obese mice (Neelakantan et al., 2018)

• Restored myogenic capacity and muscle mass in aged mouse models (Dimet-Wiley et al., 2022)

• Depletion of 1-methylnicotinamide and restoration of intracellular SAM

Research Protocol

Commonly studied routes: Oral, Subcutaneous. Reconstitute with bacteriostatic water. Consult published literature for dose ranges; use our Peptide Calculator for volumetric preparation.

Storage

-20°C desiccated; protect from light

Important Notice

5-Amino-1MQ (10mg) is supplied for laboratory research use only (RUO). Not for human or veterinary use, diagnostics, or therapeutics.