Glutathione (1500mg)

Research Overview

The most abundant intracellular thiol-based antioxidant, present at 1-10 mM in most mammalian cells. Its free sulfhydryl group on the central cysteine is directly oxidized to GSSG by reactive oxygen species and is regenerated by NADPH-dependent glutathione reductase. Central to Phase-II detoxification, redox signaling, and maintenance of protein thiol status.

Origin: Endogenous tripeptide antioxidant present in all aerobic cells; the principal intracellular redox buffer

Mechanism of Action

• Direct quenching of reactive oxygen and nitrogen species

• Cofactor for glutathione peroxidase and glutathione S-transferase

• Phase-II hepatic conjugation of xenobiotics

• Regeneration of vitamin C and vitamin E radicals

• Regulation of protein S-glutathionylation

Primary Research Areas

• Oxidative stress and ageing

• Hepatic detoxification research

• Neurodegenerative models (Parkinson's)

• Mitochondrial dysfunction

• Redox signaling

Key Published Findings

• Intracellular GSH depletion is a hallmark of dopaminergic neurodegeneration in Parkinson's (Sian et al., Ann Neurol 1994)

• Restores mitochondrial respiratory capacity in oxidative-stress models

• Central role in the γ-glutamyl cycle and Phase-II detoxification pathways

Research Protocol

Commonly studied routes: Intravenous, Subcutaneous, Oral. Reconstitute with bacteriostatic water. Consult published literature for dose ranges; use our Peptide Calculator for volumetric preparation.

Storage

-20°C lyophilized, protect from air and light

Important Notice

Glutathione (1500mg) is supplied for laboratory research use only (RUO). Not for human or veterinary use, diagnostics, or therapeutics.