MOTS-c (10mg)

Research Overview

The first mitochondrial-derived peptide shown to have metabolic signaling functions. MOTS-c is encoded within the mitochondrial genome and acts as a retrograde signal from mitochondria to the nucleus, bridging mitochondrial function with metabolic regulation.

Origin: Encoded in mitochondrial 12S rRNA gene; discovered by Lee et al., 2015

Mechanism of Action

• AMPK activation

• Folate-methionine cycle regulation

• De novo purine synthesis modulation

• Nuclear translocation under stress

• Mitochondrial-nuclear signaling

Primary Research Areas

• Metabolic regulation

• Exercise mimetics

• Insulin sensitivity

• Aging

• Mitochondrial biology

Key Published Findings

• Activated AMPK and improved insulin sensitivity in obese mice (Lee et al., 2015)

• Circulating levels decline with age and are restored by exercise

• Translocated to nucleus under metabolic stress to regulate gene expression

Research Protocol

Commonly studied routes: Subcutaneous. Reconstitute with bacteriostatic water. Consult published literature for dose ranges; use our Peptide Calculator for volumetric preparation.

Storage

-20°C lyophilized

Important Notice

MOTS-c (10mg) is supplied for laboratory research use only (RUO). Not for human or veterinary use, diagnostics, or therapeutics.