NAD+ (500mg)

Research Overview

A pyridine dinucleotide coenzyme central to oxidative metabolism, the sirtuin family of deacetylases, the PARP family of DNA-repair enzymes, and CD38 ectoenzyme signaling. Cellular NAD+ levels decline markedly with age — a phenomenon directly implicated in mitochondrial dysfunction and many hallmarks of aging.

Origin: Essential coenzyme present in every living cell; biosynthesized from tryptophan, nicotinic acid, or nicotinamide riboside

Mechanism of Action

• Hydride carrier in redox reactions (NAD+/NADH)

• Cosubstrate for sirtuin-family deacylases (SIRT1-7)

• Substrate for PARP-family DNA-damage response enzymes

• Substrate for CD38 cyclic-ADP-ribose signaling

• Regulator of circadian-clock CLOCK:BMAL1 activity

Primary Research Areas

• Geroscience and ageing

• Mitochondrial dysfunction

• Neurodegeneration and DNA repair

• Metabolic dysfunction (NAFLD, insulin resistance)

• Circadian biology

Key Published Findings

• Supplementation with NAD+ precursors restored mitochondrial function in aged mice (Gomes et al., Cell 2013)

• NAD+ decline is a hallmark of ageing across tissues (Verdin, Science 2015)

• Sirtuin activity is rate-limited by NAD+ availability

Research Protocol

Commonly studied routes: Intravenous, Subcutaneous. Reconstitute with bacteriostatic water. Consult published literature for dose ranges; use our Peptide Calculator for volumetric preparation.

Storage

-20°C lyophilized, desiccated, protect from light

Important Notice

NAD+ (500mg) is supplied for laboratory research use only (RUO). Not for human or veterinary use, diagnostics, or therapeutics.