Semax (5mg)

Research Overview

A heptapeptide derived from the ACTH(4-10) fragment, developed at the Institute of Molecular Genetics. Unlike the parent ACTH molecule, Semax lacks corticotropic and steroidogenic activity, instead focusing on nootropic and neuroprotective pathways.

Origin: Synthetic analog of ACTH(4-10) fragment with Pro-Gly-Pro extension

Mechanism of Action

• BDNF & NGF upregulation

• TrkB receptor activation

• Dopaminergic & serotonergic modulation

• Acetylcholinesterase inhibition

• CREB phosphorylation enhancement

Primary Research Areas

• Neuroprotection

• Stroke recovery

• Cognitive enhancement

• Attention disorders

• Neurotrophic factor research

Key Published Findings

• Upregulated BDNF by 1.4–3x in rat hippocampus after intranasal administration

• Demonstrated neuroprotective effects in rat MCAO stroke model

• Improved spatial memory in Morris water maze tests

Research Protocol

Commonly studied routes: Intranasal, Subcutaneous. Reconstitute with bacteriostatic water. Consult published literature for dose ranges; use our Peptide Calculator for volumetric preparation.

Storage

-20°C lyophilized

Important Notice

Semax (5mg) is supplied for laboratory research use only (RUO). Not for human or veterinary use, diagnostics, or therapeutics.