Somatropin (HGH) (36IU)

Research Overview

A 191-amino-acid single-chain polypeptide hormone produced via recombinant DNA technology. Binds the growth hormone receptor (GHR) to trigger JAK2-STAT5 signaling, driving IGF-1 production in the liver and exerting direct anabolic, lipolytic, and metabolic effects across peripheral tissues.

Origin: Produced by recombinant E. coli expression; sequence identical to pituitary-derived human GH

Mechanism of Action

• GHR receptor dimerization

• JAK2-STAT5 signal transduction

• Hepatic IGF-1 induction

• Direct lipolysis via hormone-sensitive lipase

• Counterregulation of insulin

Primary Research Areas

• GH deficiency models

• Sarcopenia and aging

• Body composition research

• Wound healing and post-surgical recovery

• Metabolic research

Key Published Findings

• Reduced visceral adiposity and improved lipid profile in GH-deficient adults (Johannsson et al., 1997)

• Increased lean body mass and decreased fat mass in hypopituitary cohorts (Cuneo et al., 1991)

• Restored IGF-1 to youthful levels in aged subjects (Rudman et al., NEJM 1990)

Research Protocol

Commonly studied routes: Subcutaneous. Reconstitute with bacteriostatic water. Consult published literature for dose ranges; use our Peptide Calculator for volumetric preparation.

Storage

Lyophilized powder stored at 2-8°C. Reconstituted solution 2-8°C, do not freeze

Important Notice

Somatropin (HGH) (36IU) is supplied for laboratory research use only (RUO). Not for human or veterinary use, diagnostics, or therapeutics.