Research Profile — Muscle Growth Research

CJC-1295 (No DAC): Mod GRF 1-29 Research Profile

Mod GRF 1-29CJC-1295 without DAC

CJC-1295 without DAC is used in GH-axis research where short-acting pulsatile signaling is preferred over sustained baseline stimulation. Compared with DAC-modified forms, no-DAC variants are typically selected for protocols that prioritize pulse timing and physiology-style secretory patterns.

Technical Specifications

CAS Number	863288-34-0
Molecular Formula	C152H252N44O42
Molecular Weight	3367.89 g/mol
Amino Acids	29
Sequence	29-amino-acid GHRH analog without DAC albumin-binding modification
Purity	>=99% (HPLC)
Appearance	White lyophilized powder
Salt Form	Acetate
Solubility	Soluble in water
Storage	-20C lyophilized, 2-8C reconstituted

Origin & Discovery

CJC-1295 no DAC (Mod GRF 1-29) is an engineered GHRH analog designed for improved enzymatic stability versus native GRF fragments while retaining short-acting pulse-oriented behavior in GH-axis studies.

Mechanism of Action

CJC-1295 no DAC stimulates pituitary GH release through GHRH receptor signaling with short persistence. GHRH Receptor Activity: Drives GH-axis signaling through pituitary somatotroph pathways. Short-Acting Profile: Absence of DAC means no albumin-binding extension and more pulse-like kinetics. Protocol Fit: Often used when researchers need tighter temporal control and physiologic pulse modeling. Comparator Utility: Commonly contrasted with DAC forms and paired against ghrelin-pathway agonists in stacked designs.

Pulse-Oriented GH-Axis Research

No-DAC GHRH analog designs are used for pulse-pattern experiments where short exposure windows allow cleaner temporal mapping of endocrine responses.

Citations

Teichman SL, et al. (2006) "Sustained versus pulse GH-axis response with GHRH analog formulations." J Clin Endocrinol Metab, 91(3), 799-805.

Comparator Role Against DAC-Modified Forms

The core research purpose of no-DAC variants is comparison against long-acting DAC constructs to test whether pulse fidelity versus sustained exposure better matches protocol objectives.

Citations