Research Profile — Muscle Growth Research

Sermorelin: Complete GHRH Analog Research Profile

GRF 1-29GHRH(1-29)NH2 analog

Sermorelin is a GHRH analog used in GH-axis studies to model receptor-mediated pituitary stimulation closer to endogenous hypothalamic signaling architecture. It is commonly used as a comparator against ghrelin-pathway secretagogues and in multi-arm protocol designs that evaluate pulse quality, axis responsiveness, and longitudinal endocrine marker shifts.

Technical Specifications

CAS Number	86168-78-7
Molecular Formula	C149H246N44O42S
Molecular Weight	3357.77 g/mol
Amino Acids	29
Sequence	Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-NH2
Purity	>=99% (HPLC)
Appearance	White lyophilized powder
Salt Form	Acetate
Solubility	Soluble in water
Storage	-20C lyophilized, 2-8C reconstituted

Origin & Discovery

Sermorelin is a synthetic analog of growth hormone-releasing hormone comprising the active 1-29 amino-acid sequence required for pituitary GH-receptor signaling in endocrine research contexts.

Mechanism of Action

Sermorelin works primarily through growth hormone-releasing hormone receptor activation on pituitary somatotroph cells. GHRH Receptor Signaling: Stimulates GH release through the endogenous GHRH axis pathway. Physiology-Oriented Use: Often selected when protocol goals emphasize closer alignment with hypothalamic-pituitary signaling logic. Comparator Role: Frequently compared against or combined with GHSR agonists to study receptor-pathway complementarity. Pulse and Timing Factors: Outcomes are sensitive to timing, baseline axis status, and study duration.

GHRH Fragment Activity and Pituitary Response

Work on GHRH fragment analogs established the 1-29 region as functionally active for pituitary GH release, which underpins sermorelin's role in receptor-specific GH-axis research.

Citations

Mayo KE, et al. (1985) "Growth hormone-releasing hormone and pituitary signaling biology." Endocr Rev, 6(4), 497-513.

Clinical and Translational GH-Axis Context

Sermorelin has been used in endocrine contexts to evaluate GH-axis responsiveness and to compare physiology-linked stimulation against other secretagogue routes. In research design, it often functions as the GHRH-pathway anchor in comparator and stack protocols.

Citations